Acromegaly
Growth Hormone Excess

Acromegaly develops slowly — most patients are diagnosed years after symptoms begin. The excess growth hormone (GH) stimulates the liver to produce IGF-1, which drives abnormal growth of bones, soft tissues, and organs.

If untreated, acromegaly significantly increases the risk of diabetes, hypertension, heart disease, and colorectal cancer. Early treatment — surgery, radiation, or medication — can prevent these complications.

Enlarged Hands & Feet

Rings no longer fit; shoes need a larger size. Hands and feet grow gradually due to excess GH.

Coarse Facial Features

Brow ridge, jaw, and nose enlarge. Teeth may separate. Tongue may thicken.

Fatigue & Sleep Apnoea

Most acromegaly patients have obstructive sleep apnoea due to jaw and throat changes.

Joint Pain

Cartilage overgrowth causes arthritis-like joint pain, especially in knees and hips.

Headaches & Vision Changes

The pituitary tumour can press on optic nerves, causing headaches and visual field defects.

High Blood Sugar

Excess GH causes insulin resistance. Diabetes develops in up to 25% of acromegaly patients.

IGF-1 Blood Test

Elevated IGF-1 is the primary screening test for acromegaly. A single fasting sample is sufficient.

GH Suppression Test

75g oral glucose normally suppresses GH below 1 ng/mL. Failure to suppress confirms acromegaly.

MRI Pituitary

Gadolinium-enhanced MRI identifies the pituitary adenoma — size determines surgical approach.

Visual Field Testing

Perimetry checks for bitemporal hemianopia if the tumour presses on the optic chiasm.

Acromegaly and GH excess disorders require specialist-level expertise to diagnose and manage. Dr. Rizwan Niazi has over 18 years of experience treating complex hormone conditions including pituitary tumours, IGF-1 excess, and GH abnormalities.

• MBBS, MRCP, MCPS, MD — Endocrinology
• Specialised pituitary disorder evaluation
• MRI and IGF-1 guided treatment plans
• Clinic: DHA Phase 5, Lahore